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Vascular Targeting Agents: Emerging Competitors

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Published Date Feb 8, 2005
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Quick Overview

An update on the most recent advances made for vascular targeting agents that are now entering an exciting stage of development.

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Executive Summary

In this issue of Cancer Highlights, BioSeeker Group analyzes the progress made for vascular targeting agents (VTA). You will receive an update on the most recent advances made for vascular targeting agents that are now entering an exciting stage of development. In only a few years time the number of candidates has been doubled, expanding from a handful of drugs to more than twenty. Several of these have entered clinical evaluation. Earlier and most talked of candidates still remain at the top. However, the list of emerging competitors is growing and at least seven new VTAs have recently entered clinic settings. Not so far away, there are also several vascular targeting agents that are on the brim of initiating Phase I trials.

Vascular targeting agents with the longest clinical experience are the small molecular drugs that mediate their action on the tubulin cytoskeleton. In review of 2004, several companies have announced progression on existing studies. In addition two new Phase II trials and two new Phase I trials have been launched. Several companies have made announcements of plans to initiate new trials during 2005. A few candidates are now in planning for Phase III trial studies.

Despite compelling preclinical data, the conjugated antibodies have been delayed in comparison to the small molecule approaches. Trial initiation is thus long overdue for many. We have devoted an entire section of this Highlight to "Monoclonal antibodies as Delivery Vehicles" where the progression for several of the most important conjugated antibodies is outlined. One of these antibodies is already in Phase I and for which plans are laid for Phase II during 2005.

The close relation between vascular targeting and anti-angiogenesis also make it possible for new competitors to enter the scene in near future. One relative large company, with a strong anti-angiogenesis antibody portfolio, has already announced to hold a vascular targeting antibody in early stage of development.

In total BioSeeker Group has identified 26 different therapies that have been developed utilizing vascular targeting strategies:

3G4, ABT-751, AVE8062A, AZD4440, BCH-19746, BCH-23541, CA4P, DMXAA, E4G10, EndoTAG-1, EndoTAG-2, Exherin, ILX-651, MLN2704, MLN591, MLN591RL, MN-029, MX116407, NPI-2358, OXi4503, OXi6197, OXi8009, Tarvacin, TZT-1027, VEGF121/rGel, ZD6126

Introduction
More Vascular Targeting Drugs in Clinical Trial
Table 1 Summary of VTA agents under development
The Vanguard VTA in New Clinical Programs
Combination of VTAs and antiangiogenic agents
The Non-Combretastatins Agents that Destabilize Microtubules
Antimicrotubule Agents with Vascular Targeting Potential
Monoclonal Antibodies as Delivery Vehicles
Targeting Endothelial Cell-Specific Adhesion
Encapsulation in cationic liposomes

Disclaimer
Liability
Completeness

Appendix

List of Tables

Table 2. CA4P Near Term Progress
Table 3. Oxi 4503 Near Term Progress
Table 4. AVE8062A Near Term Progress
Table 5. ZD6126 Near Term Progress
Table 6. DMXAA Near Term Progress
Table 7. ABT-751 Near Term Progress
Table 8. MN-029 Near Term Progress
Table 9. MX116407 Near Term Progress
Table 10. NPI-2358 Near Term Progress
Table 11. TZT-1027 Near Term Progress
Table 12. ILX-651 Near Term Progress
Table 13. Peregrines VTA and APT platforms Near Term Progress
Table 14. VEGF121/rGelonin Near Term Progress
Table 15. MLN2704 Near Term Progress
Table 16. Adherexs cadherin platform Near Term Progress
Table 17. E4G10 Near Term Progress
Table 18. EndoTAG-1 Near Term Progress

Drugs covered in this report:
3G4, ABT-751
AVE8062A
AZD4440
BCH-19746
BCH-23541
CA4P
DMXAA
E4G10
EndoTAG-1
EndoTAG-2
Exherin
ILX-651
MLN2704
MLN591
MLN591RL
MN-029
MX116407
NPI-2358
OXi4503
OXi6197
OXi8009
Tarvacin
TZT-1027
VEGF121/rGel
ZD6126

Request Sample Pages or Access via 1stOncology™

  • You can request Free Sample Pages to Vascular Targeting Agents: Emerging Competitors.
    To find out more about Vascular Targeting Agents: Emerging Competitors, please read the product description below.
    We also are happy to email you out free sample pages which contain screen shots and more information on the methodology behind the product.

    Did you know that Vascular Targeting Agents: Emerging Competitors is part of the 1stOncology™ platform and can be accessed at no extra cost?

    1stOncology™ allows you to always stay on top of what is really going on in the world of cancer drug development and have an edge when it comes to Search & Evaluation, Indication Selection & Expansion, Target Scouting, First-in-Class analysis and much, much more.


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