Executive Summary
BioSeeker Group have identified 172 companies plus partners who are today developing 222 IL-3 pathway targeting drugs in 789 developmental projects in cancer across 129 different targets. In addition, there are 4 suspended drugs and another 82 drugs where development has been ceased.
For busy executives within Pharma, Biotech and Investment companies who know they need to stay on top of the developmental environment in their field, we offer the Drug Pipeline update series.
You get detailed, world-wide drug pipeline information, delivered in an unbiased and independent pipeline progress analysis for each identified drug.
Buying the IL-3 Signaling Pathway in Oncology Drug Pipeline Update 2013 will mean you have this important data at your fingertips and ensure that you can:
* Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
* Find competitors, collaborations partners, M&A candidates etc. and track them by their products.
* Jump start competitive drug intelligence operations
* Benchmark your own development against world wide data
* Compare portfolio and therapy focus with your peers
* Speed up pro-active in-/outlicensing strategy work
Our software lets you define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.
The following short video playlist demonstrates the use of the filter sections, how you can make an inclusion and exclusion search and what to expect from a drug profile result.
Some facts about IL-3 Signaling Pathway in Oncology Drug Pipeline Update 2013
The IL-3 signaling pathway activates the JAK/STAT, MAPK and PI 3-kinase signaling modules.
There are today 172 companies plus partners developing 222 IL-3 pathway targeting drugs in 789 developmental projects in cancer. In addition, there are 4 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 82 drugs. Il-3 Signaling Pathway In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 129 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 116 out of the 128 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 32 classifications of molecular function and with pathway referrals to BioCarta, KEGG. NCI-Nature and NetPath.
Details from IL-3 Signaling Pathway in Oncology Drug Pipeline Update 2013 at a glance
This short overview shows actual findings from the IL-3 Signaling Pathway in Oncology Drug Pipeline Update 2013 report.
| Companies | Includes more than 172 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies. Note: You are able to sort and find drugs according to companiess and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies. |
| Drug name & Synonyms | Lists commercial, generic and code names for drugs. |
| Developmental stage | This Drug Pipeline Update contains 222 IL-3 pathway targeting drugs in development, which have a total of 789 developmental projects in cancer. In addition there are suspended and ceased drugs. Pipeline Breakdown According to Number of Drugs Marketed# 19 Registered# 1 Pre-registration# 2 Phase III# 22 Phase II# 79 Phase I# 88 Preclinical# 128 No Data# 1 Suspended# 4 Ceased# 82 Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application. |
| Indications | Included IL-3 pathway targeting drugs are also in development for 127 other indications, where of 75 are different cancer indications. Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application. |
| Targets | Mutations All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 116 out of the 128 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. Biological Structures The identity of available biological structures on 111 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 2297 structures available today among drug targets. Identified drugs are linked to more than 129 different targets, divided into 32 classifications of molecular function: - ATPase activity - Catalytic activity - Chaperone activity - Cysteine-type peptidase activity - Cytokine activity - DNA repair protein - G-protein coupled receptor activity - Growth factor activity - GTPase activity - Kinase activity - Kinase binding - Ligand-dependent nuclear receptor activity - Lipid kinase activity - Lipid phosphatase activity - Molecular function unknown - Oxidoreductase activity - Protein binding - Protein serine/threonine kinase activity - Protein threonine/tyrosine kinase activity - Protein tyrosine phosphatase activity - Protein tyrosine/serine/threonine phosphatase activity - Protein-tyrosine kinase activity - Receptor activity - Receptor binding - Receptor signaling complex scaffold activity - Receptor signaling protein serine/threonine kinase activity - Structural constituent of cytoskeleton - Transcription factor activity - Transcription regulator activity - Transmembrane receptor activity - Transmembrane receptor protein tyrosine kinase activity - Transporter activity Sub-Cellular Localization Identified targets are categorized into 25 different primary and alternate sub-cellular localizations: - Cell projection - Centrosome - Chromosome - Clathrin-coated vesicle - Cytoplasm - Cytoplasmic vesicle - Cytoskeleton - Cytosol - Endoplasmic reticulum - Endosome - Extracellular - Extracellular matrix - Golgi apparatus - Lysosome - Microtubule - Mitochondrial membrane - Mitochondrion - Nuclear membrane - Nucleolus - Nucleus - Perinuclear region - Perinuclear vesicle - Plasma membrane - Secreted - Vesicle Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application. |
| Target Expression Profile | Direct links are provided from inside the application to 206 protein expression profiles of 123 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to: - 48 different normal tissue types - 20 different types of cancer - 47 cell lines - 12 samples of primary blood cells |
| Pathway Referals | Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath. - BioCarta# 217 Pathways - KEGG# 123 Pathways - NCI-Nature# 238 Pathways - NetPath# 25 Pathways Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application. |
| Mechanism | In total there are different drug mechanism of action represented in this Drug Pipeline Update. Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application. |
| Compound | Identified drug compounds are described by: Compound type, Chemical name, CAS Number and molecular weight Note: You are able to sort and find drugs according to compound type from drop-down menu in the application. |
The Drug Profiles: Progress analysis and review of drug development.
IL-3 Signaling Pathway in Oncology Drug Pipeline Update 2013 provides you with a profile for each identified drug.
Click here for a short video (6m 12s) showing a typical drug profile
A typical drug profile reports on, depending on stage of development and available information:
| Drug Name & Synonyms | Presentation of drug name and synonyms. |
| Principal Company & Partners | Presentation of principal Company and partners. |
| Target and Molecular Function of Target | Described target(s) is/are presented with: Official Gene Symbol – Chromosome Location – Gene & Protein Name – Molecular Function |
| Target Localization | Described target(s) is/are presented with primary and alternate localizations. Target Expression Profiles Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to: 48 different normal tissue types 20 different types of cancer 47 cell lines 12 samples of primary blood cells |
| Mutation | All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. |
| Biological Structures | The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist. |
| Targeted Pathways | Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath. |
| Mechanism | Drug mechanism of action |
| Developmental Projects | Summary field of developmental projects for the drug, including indication, developmental stage and status. Example: Cancer, myeloma – Phase II Clinical Trial – Active Cancer, prostate – Phase III Clinical Trial – Ceased |
| Drug Description | Short introduction to drug |
| Compound Data | Compound type, Chemical name, CAS Number and molecular weight. |
| Patent Data | Available patent information related to the drug is presented here. |
| Fillings and Approvals | Approvals and submissions Analyst comments |
| Deals and Licensing | Collaborations and deals Availability for licensing |
| Phase IV Data | Available Phase IV development data, developmental history and scientific data. |
| Phase III Data | Available Phase III development data, developmental history and scientific data. |
| Phase II Data | Available Phase II development data, developmental history and scientific data. |
| Phase I Data | Available Phase I development data, developmental history and scientific data. |
| Phase 0 Data | Available Phase 0 development data, developmental history and scientific data. |
| Preclinical Data | Available Preclinical data, developmental history and scientific data. |
| Discovery Data | Available discovery development data, developmental history and scientific data., developmental history and scientific data. |
About the unique Drug Pipeline Update Software Application
After purchase, the Drug Pipeline Update is delivered to you via electronic download in a powerful yet easy to use desktop application which requires no installation.
Find and sort drugs by twenty-four different parameters, all of which can be used as inclusion or exclusion parameters, plus free text search field. Our dynamic report generator lets you easily and quickly generate HTML drug profile reports directly in your web browser, whether it is a single drug profile or your own report of a selection of drugs that match your criteria.
| Application Features | Search, Find and Filter Panel with Initial Result Presentation With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter. Click here for a short video (2m 14s) showing an overview of the filters. The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords. Click here for a short video (3m 26s) showing an example of an inclusion and exclusion search to create the initial results table. Direct linkage from inside the application to related internet resources - Drug data is linked to search engines like Google and PubMed - Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc. - Direct links to company web pages of companies Dynamic Report Generator Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of. Click here for a short video (6m 12s) showing a typical drug profile |
| System Requirements | - Operating system: Windows (2000/XP/Vista/7) and Mac OS X 10.6 (Snow Leopard) and OS X 10.7 (Lion) - Browser Application (Internet Explorer) - Internet access (to access related internet resources) |
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